Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients
Starting soon · Phase 4 · Has a placebo group
Conditions studied: Elderly, Noncardiac Surgery, Delayed Neurocognitive Recovery, Postoperative Delirium, Esketamine
In brief
Esketamine is frequently used during the perioperative period for supplemental analgesia. Small sample size trials showed that subanesthetic dose esketamine may decrease postoperative neurocognitive complications. However, conflicting results exist and optimal dose of esketamine remains to be determined. This dose-exploring pilot trial is designed to evaluate the safety and efficacy of three different perioperative esketamine dosing regimens in older patients undergoing major non-cardiac surgery. The primary purpose is to explore the optimal dosing strategy that produce maximal neurocognitive benefits with minimal adverse neuropsychiatric symptoms.
Key facts
- Study ID
- NCT07523334
- Run by
- Peking University First Hospital
- People needed
- 120
- Starts
- 2026-04-01
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-04-14
Who can join
Age: 65 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aged >=65 but <= 90 years;
- Scheduled to undergo non-cardiac surgery with an expected duration of >= 2 hours under general anesthesia;
- Requiring patient-controlled intravenous analgesia (PCIA) after surgery.
You may not qualify if…
- Unable to communicate preoperatively due to visual or auditory impairment, language barrier, or severe dementia;
- Comorbid with schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis;
- Traumatic brain injury or neurosurgery;
- Severe hepatic dysfunction (Child-Pugh Class C), severe renal dysfunction (receiving dialysis preoperatively), or American Society of Anesthesiologists physical status classification >= Ⅳ;
- Expected admission to the Intensive Care Unit with endotracheal intubation after surgery;
- Anaphylaxis to esketamine;
- Participation in other clinical studies, or any other conditions that are considered unsuitable to be involved in the study.
Where it is running
- Peking University First Hospital — Beijing, Beijing Municipality, China
- Tianjin Medical University General Hospital — Tanjing, Tianjing, China
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.