Assessment of Sexual Quality of Life Following Local Treatment (Radiotherapy With or Without Surgery) in Patients With HPV-positive Pelvic Cancer: a Descriptive Longitudinal Study

Starting soon · Not applicable

Conditions studied: Pelvic Cancer, Anal Cancer, Vaginal Cancer

In brief

In patients with cancer associated with human papillomavirus (HPV), the physical effects of treatment, combined with the psychosexual impact linked to HPV status, can further impair the quality of sexual life. However, few studies have examined the specific effect of HPV status (or knowledge of status) on the recovery/quality of sexuality following radiotherapy. It is against this backdrop that we propose a prospective longitudinal study specifically dedicated to investigating the sexual quality of life of women with HPV-positive pelvic cancer. This type of study will enable better quantification and description of sexual dysfunction occurring after treatment, and assessment of the impact of HPV carriage, with the future aim of guiding new prevention and management strategies.

Key facts

Study ID

NCT07523152

Run by

Institut du Cancer de Montpellier - Val d'Aurelle

People needed

42

Starts

2026-04-02

Expected to finish

2027-10-31

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Women aged 18 or over.
• Sexually active patients, i.e. those who have been sexually active in the year prior to their cancer diagnosis.
• Patients being treated at the Montpellier Cancer Institute (ICM).
• Patient with pelvic squamous cell carcinoma (cervix, vagina, vulva or anus) and human papillomavirus (HPV+) infection
• Patient aware of her HPV status and how it is transmitted.
• Indicated for external radiotherapy
• Patient who has not received any oncological treatment prior to inclusion.
• Patient who has given verbal consent.

You may not qualify if…

• Patients receiving radiotherapy treatment outside the Montpellier Cancer Institute (ICM).
• Patients who are unwilling or unable to complete the study questionnaires.
• Patients under guardianship, curatorship or court protection,
• Patients for whom regular follow-up is impossible for psychological reasons,
• Patients who do not speak French.

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