Colorectal Adenoma Cohort
Starting soon
Conditions studied: Colorectal Neoplasms
In brief
This is an ambidirectional cohort study aiming to develop and validate a risk prediction model for colorectal adenoma recurrence and progression. The study will enroll patients aged 18-75 years who undergo colorectal adenoma resection at the Second Affiliated Hospital of Zhejiang University School of Medicine. A retrospective cohort will include patients treated in the past 10 years with available endoscopic, pathologic, and routine laboratory data. A prospective cohort will be enrolled from the date of ethical approval until December 31, 2030, with collection of epidemiological questionnaire data, lifestyle information, blood and tissue biospecimens, and follow-up outcomes. The primary outcome is adenoma recurrence, with secondary outcomes including advanced adenoma and colorectal cancer. Based on a target of 1,083 evaluable participants (325 events) to ensure adequate model development, and accounting for 15% loss to follow-up, the total planned enrollment is 1,280 participants. The study will validate existing risk models based on traditional adenoma characteristics and establish a novel model incorporating lifestyle factors and systemic inflammatory markers to improve risk stratification and guide surveillance strategies.
Key facts
- Study ID
- NCT07523035
- Run by
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- People needed
- 1280
- Starts
- 2026-04-16
- Expected to finish
- 2033-12-31
- Last updated by the study team
- 2026-04-13
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who underwent colonoscopy at our institution, were diagnosed with colorectal adenoma, and underwent adenoma resection.
- Aged between 18 and 75 years.
- Provide written informed consent voluntarily, with willingness to comply with follow-up procedures.
- For the retrospective cohort only: Regular follow-up colonoscopy at our institution within 1 to 5 years after adenoma resection.
You may not qualify if…
- Severe dysfunction of vital organs (e.g., heart, liver, kidney).
- Psychiatric disorders that preclude normal communication or compliance with study procedures.
- History of colorectal cancer.
- Recent receipt of radiotherapy or chemotherapy.
- Pregnancy or lactation.
Full record on ClinicalTrials.gov
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