Adherence to Dyslipidemia Therapy: Harnessing Evidence From Randomized Evaluations in AtheroSclerotic CardioVascular Disease
Running, not enrolling · Not applicable
Conditions studied: ASCVD, Diabetes
In brief
The goal of the ADHERE-ASCVD study is to evaluate and optimize patient-facing messaging strategies to improve statin refill and adherence among adults with atherosclerotic cardiovascular disease (ASCVD) or diabetes. The main questions it aims to answer are: 1. Do different outreach methods (such as text messages, secure portal messages, or email) increase short-term statin refill compared to usual care? 2. Among patients who do not initially refill their prescription, does changing the outreach method improve refill rates? The team with operational partners will evaluate the comparitive effectivessness of multiple messaging strategies delivered through existing health system communication channels, including SMS (text messaging), secure patient portal messages, non-secure email, and usual care (no additional outreach). Participants * Receive an initial outreach message encouraging statin refill (or usual care) Be monitored for statin refill within 14 days * Potentially receive a second outreach message using the same or a different communication method if they do not initially refill their prescription * Have their medication refill patterns tracked over time, including longer-term adherence outcomes
Key facts
- Study ID
- NCT07522645
- Run by
- Kaiser Permanente
- People needed
- 22000
- Starts
- 2026-04-14
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-07-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Active Kaiser Permanente Northern California (KPNC) membership
- Diagnosis of atherosclerotic cardiovascular disease (ASCVD) or diabetes and inclusion in the Preventing Heart Attacks and Strokes Everyday (PHASE) Registry
- No statin prescription fill within the prior 3 months
- Statin adherence <80% in the prior 12 months
- Active kp.org account within the past 12 months
- Valid email address and text-capable phone number on file
You may not qualify if…
- Documented allergic reaction or contraindication to statin therapy
- Receiving hospice care
- Medicare beneficiaries
- Other exclusions applied per operational standard practice
Where it is running
- Kaiser Permenante Northern California — Pleasant Hill, California, United States
Full record on ClinicalTrials.gov
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