A Clinical Study to Evaluate the Efficacy and Safety of VG2025 in Intrahepatic Cholangiocarcinoma

Starting soon · Phase 2

Conditions studied: Intrahepatic Cholangiocarcinoma

In brief

VG2025 is a Recombinant Human IL12/15 Dual-Regulated Oncolytic HSV-1 Injection. Currently, one phase I dose escalation safety study has been completed in China and the United States respectively, both demonstrating excellent safety profiles with no dose-limiting toxicities (DLTs) observed and no maximum tolerated dose (MTD) identified. Moreover, it has shown preliminary efficacy in treating advanced tumors. Considering the actual clinical needs and the volume of intratumoral administration, a more appropriate recommended phase 2 dose (RP2D) level has been selected for the phase II clinical trial.

Key facts

Study ID

NCT07522476

Run by

Virogin Biotech Ltd.

People needed

30

Starts

2026-07-01

Expected to finish

2028-11-13

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Signed written informed consent form.
• Age 18 to 75 years (inclusive), male or female.
• Histologically or cytologically confirmed advanced intrahepatic cholangiocarcinoma.
• Eligible participants of childbearing participants(male and female) must agree to use a reliable method of contraception during the trial and for at least 90 days after dosing; females of childbearing potential must have a negative blood pregnancy test 7 days before enrollment.

You may not qualify if…

• Participants who have received other unlisted drugs clinical trial treatment 4 weeks before the first dose of the study drug.
• Participants who underwent major organ surgery (excluding needle biopsy) or had significant trauma 4 weeks before the first dose of the study drug.
• In the herpes simplex virus recurrence and infection period, and there are corresponding clinical manifestations, such as oral herpes labialis, herpetic keratitis, herpetic dermatitis, genital herpes and so on.
• Other active uncontrolled infection.
• Known alcohol or drug dependence.
• Participants with mental disorders or poor compliance.
• Women who are pregnant or breastfeeding.
• Participants in the opinion of the investigator are not suitable for this clinical study due to other serious systemic diseases or other reasons.

Where it is running

• The First Affiliated Hospital，Zhejiang University School of Medicine — Hangzhou, Zhejiang, China

Full record on ClinicalTrials.gov

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