Comparison of Frailty, Physical Fitness Parameters, and Irisin Levels Between Patients With Multiple Sclerosis and Healthy Volunteers

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Conditions studied: MULTIPL SCLEROSİS

In brief

Multiple Sclerosis (MS) is a chronic immune-mediated and neurodegenerative disease of the central nervous system that often affects young adults and is more common in women. In addition to neurological disability, individuals with MS frequently experience frailty, a condition characterized by reduced physiological reserve, weakness, fatigue, decreased physical activity, and increased vulnerability to stressors. Frailty in MS is associated with poorer mobility, higher fall risk, reduced quality of life, and increased healthcare utilization. Irisin, a hormone released from skeletal muscles during exercise, is linked to energy metabolism and muscle function, and lower levels have been associated with reduced physical performance and sarcopenia. However, the relationship between frailty, physical fitness, and irisin levels in individuals with MS has not been sufficiently explored. This study aims to compare frailty status, physical fitness parameters, and circulating irisin levels between patients with MS and healthy volunteers aged 18-65 years. Participants will undergo assessments including the Functional Independence Measure, Frailty Index, Berg Balance Scale, 6-Minute Walk Test, and handgrip strength measurement. Blood samples will also be collected to determine irisin levels using the ELISA method. Statistical analyses will evaluate differences between groups and correlations among frailty, functional performance, and irisin levels. The findings are expected to improve understanding of frailty mechanisms in MS and contribute to developing targeted rehabilitation and management strategies.

Key facts

Study ID: NCT07521982
Run by: Baskent University
People needed: 782
Starts: 2026-04-01
Expected to finish: 2026-06-30
Last updated by the study team: 2026-04-13

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Patients aged 18-65 evaluated by neurology and diagnosed with definitive MS via objective methods (MRI, lumbar puncture, etc.).
Healthy volunteers aged 18-65.
Being literate in Turkish.
Participants who provide a consent form to participate in the study.

You may not qualify if…

Being younger than 18 or older than 65.
Presence of any concomitant neurological disease other than MS.
Presence of an uncontrolled systemic disease at a level that would affect the evaluation.
Presence of cognitive impairment or psychiatric illness at a level that would affect the evaluation.
Having had an MS attack or received steroid treatment in the last month.
Presence of an orthopedic disability that prevents evaluations.

Where it is running

Baskent University Alanya Hospital — Antalya, Alanya, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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