Short-Term Safety of Low-Dose Creatine Hydrochloride: A 28-Day Single-Arm Pilot Study

Completed · Not applicable

Conditions studied: Safety of Short Term Creatine Hydrochloride Dosing

In brief

Background: Creatine monohydrate (typically 5-20 g/day) has a well-established safety profile across diverse populations. Creatine hydrochloride (CR-HCl) is a highly soluble creatine formulation that may allow effective supplementation at substantially lower doses (750 mg - 3 g/day); however, controlled human safety data specific to CR-HCl remain limited. Objective: To evaluate the short-term laboratory safety and tolerability of low-dose CR-HCl supplementation administered for 28 days in healthy adults.

Key facts

Study ID

NCT07521059

Run by

Vireo Systems, Inc.

People needed

11

Starts

2024-05-30

Expected to finish

2024-10-01

Last updated by the study team

2026-04-09

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy adults

You may not qualify if…

• consumed creatine supplements in last 30 days significant medical conditions that could affect outcomes (e.g., diabetes)

Where it is running

• Princeton Consumer Research — Raritan, New Jersey, United States

Full record on ClinicalTrials.gov

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