Neurophysiological Markers for Prediction of Rehabilitation Outcomes After Ischemic Stroke
Starting soon · Not applicable · Has a placebo group
Conditions studied: Ischemic Stroke, Upper Limb Motor Impairment
In brief
The goal of this randomized controlled study is to develop and validate an integrated neurophysiological model for predicting rehabilitation potential in patients with ischemic stroke. The study focuses on identifying objective markers of brain activity associated with motor preparation and recovery. The project includes two stages. First, healthy volunteers will participate in experimental motor and mental tasks to establish reference patterns of brain activity using electroencephalography and transcranial magnetic stimulation. These data will be used to define stable neurophysiological markers of motor network function. In the second stage, patients in the acute and early recovery phases after ischemic stroke will be randomly assigned to receive either active intermittent theta-burst stimulation of the motor cortex or a sham procedure, in addition to standard rehabilitation. Brain activity and clinical motor function will be assessed before and after the intervention. The study aims to determine which neurophysiological measures are sensitive to neuromodulation and are associated with clinical improvement, in order to construct a predictive model of rehabilitation outcome. Participants will \[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\].
Key facts
- Study ID
- NCT07520630
- Run by
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine
- People needed
- 120
- Starts
- 2026-05-01
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-04-09
Who can join
Age: 40 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- First-ever ischemic stroke confirmed by CT/MRI
- 5 days - 6 months post-stroke
- Age 40-65
- MoCA ≥20
- HADS <11 for anxiety and depression
- MRC 2-4 in upper limb
- Modified Ashworth Scale ≤3
- Signed informed consent
You may not qualify if…
- Implanted electronic devices
- Epilepsy
- Severe cardiac arrhythmias
- Intracranial aneurysm
- Decompensated somatic disease
- Pregnancy/lactation
Where it is running
- Moscow Scientific and Practical Center of Medical Rehabilitation, Restorative and Sports Medicine — Moscow, Russia
Full record on ClinicalTrials.gov
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