Microbiome-targeted Diet Therapy in Ulcerative Colitis

Starting soon · Not applicable

Conditions studied: Ulcerative Colitis

In brief

The central objective of this proposal is to test a novel diet capable of meeting the elevated protein requirements in ulcerative colitis (UC), while simultaneously decreasing microbial hydrogen sulfide (H2S) production in the colon with fiber.

Key facts

Study ID

NCT07520461

Run by

University of Minnesota

People needed

40

Starts

2026-09-07

Expected to finish

2029-06-01

Last updated by the study team

2026-08-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ability and willingness to provide informed consent
• Age at least 18 years old
• Diagnosis of UC based on clinical and endoscopic criteria
• UC duration of at least 3 months
• Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score ≤4 within 90 days of randomization
• On a stable dose or no existing UC therapies (apart from steroids) for defined periods (as outlined below).
• ≥4 weeks if no medication, 5-ASA
• ≥8 wk for immunomodulatory therapy
• ≥12 wk for biologics
• Ability to comply with study requirements in the opinion of the primary investigator

You may not qualify if…

• Moderate or severe UC as defined by UCEIS ≥5
• History of stomach surgery or bowel resection
• Antibiotic use within 3 months
• Anticipated antibiotic exposure during the study period (e.g. perioperative antibiotics)
• Pregnancy or breastfeeding
• History of anaphylactic food allergies
• Intolerance of high dietary fiber content
• Ongoing alcohol or drug abuse
• Habitual vegan diet pattern
• Insufficient freezer space to accommodate meal delivery

Full record on ClinicalTrials.gov

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