Chest X-Rays for Early Detection of Congenital Heart Disease in Newborns
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Conditions studied: Congenital Heart Disease, Chest X-ray for Clinical Evaluation, Neonates
In brief
Congenital heart disease (CHD) is a common condition affecting newborns that can be serious if not caught early. While echocardiograms are the best way to diagnose CHD, they are not always immediately available. Chest X-rays are widely available and are often the first test used when a newborn has breathing problems, a heart murmur, or a bluish skin tint. The purpose of this study is to determine how accurate standard chest X-rays are at finding congenital heart disease in newborns. Researchers will observe 60 newborns (up to 28 days old) admitted to the Neonatal Intensive Care Unit (NICU) who have signs or symptoms that suggest they might have a heart problem. Each baby in the study will receive a standard chest X-ray within 24 hours of their clinical presentation. Within 72 hours, they will also receive an echocardiogram, which is the standard, definitive test used to confirm if there is a heart defect. By comparing the initial chest X-ray results to the final echocardiogram results, researchers hope to figure out exactly which X-ray patterns are best at predicting specific heart diseases. This could help doctors make faster decisions about treating newborns, potentially reducing delays in diagnosis and improving care.
Key facts
- Study ID
- NCT07520149
- Run by
- Assiut University
- People needed
- 60
- Starts
- 2026-05-01
- Expected to finish
- 2027-06-01
- Last updated by the study team
- 2026-04-09
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Neonates aged 0-28 days admitted to the NICU with X-ray findings suspecting CHD during the study period.
- Neonates presenting with clinical signs suggestive of congenital heart disease, including: cyanosis (central or peripheral), heart murmur detected on auscultation, tachypnea, or respiratory distress.
- Neonates with abnormal pulse oximetry findings (oxygen saturation <95% in room air).
- Neonates with abnormal antenatal ultrasound findings suggesting cardiac anomalies.
You may not qualify if…
- Infants aged more than 28 days.
- Infants with no clinical or radiological evidence of CHD.
Full record on ClinicalTrials.gov
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