Effect of Escherichia Coli 5C (Colipral®) on Post-Colonoscopy Gastrointestinal Symptoms

Starting soon · Not applicable · Has a placebo group

Conditions studied: Post-Colonoscopy Gastrointestinal Symptoms

In brief

This prospective, multicenter, randomized, double-blind, placebo-controlled clinical trial will evaluate the efficacy and safety of Escherichia coli 5C (Colipral®) in adult patients undergoing diagnostic colonoscopy. Participants will be randomized in a 1:1 ratio to receive either Colipral® or placebo for 14 days immediately after colonoscopy. The study aims to determine whether Colipral® reduces post-colonoscopy gastrointestinal symptoms compared with placebo, using validated symptom and stool assessment tools, patient-reported global improvement, and safety monitoring.

Key facts

Study ID

NCT07519616

Run by

Liaquat University of Medical & Health Sciences

People needed

160

Starts

2026-04-27

Expected to finish

2026-10-30

Last updated by the study team

2026-04-09

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 18 and 80 years
• Complete diagnostic colonoscopy with achievement of the cecal fundus
• Accepted written informed consent for study participation obtained prior to the start of the study

You may not qualify if…

• Chronic inflammatory bowel disease
• Complicated Diverticular Disease (DICA >3)
• Suspected or known colorectal malignancy on index colonoscopy
• Diagnosed microscopic colitis
• Operative colonoscopy
• Severe chronic gastrointestinal symptoms judged by the investigator to interfere with the evaluation of study endpoints
• Subjects who are immunosuppressed or on systemic immunosuppressive treatment, including patients with primary or acquired immunodeficiency, oncological disease on active treatment with chemotherapy/immunotherapy, or autoimmune diseases on immunosuppressive treatment
• Taking probiotics, prebiotics, or synbiotics within 2-4 weeks prior to enrollment
• Antibiotic therapy within 4 weeks prior to enrollment
• Lack of acceptance of written informed consent

Where it is running

• University of Urbino Carlo Bo, Urbino, Italy — Urbino, Italy

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.