Neuromuscular Versus Resistance Training on Functional Capacity in Patients With Heart Failure.

Starting soon · Not applicable

Conditions studied: Heart Failure

In brief

This randomized controlled trial will compare the effects of neuromuscular training and resistance training on functional capacity, cardiorespiratory fitness, and lower limb performance in patients with chronic heart failure. A total of 40 participants will be randomly assigned into two groups in a single-blinded design. Both groups will undergo a 10-week supervised exercise program. Outcomes will be assessed using VO₂ peak, 6-Minute Walk Test (6MWT), Short Physical Performance Battery (SPPB), and quality of life measures. The study aims to determine the more effective rehabilitation approach for improving clinical outcomes in heart failure patients.

Key facts

Study ID

NCT07519473

Run by

Riphah International University

People needed

40

Starts

2026-04-01

Expected to finish

2026-07-29

Last updated by the study team

2026-04-09

Who can join

Age: 40 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female patients aged 40-60 years
• Diagnosed with chronic heart failure ≥ 1 year
• Heart failure with reduced ejection fraction (HFrEF), EF ≤ 40%
• NYHA Class II-III
• Low to moderate exercise risk (based on Chester Step Test)
• On stable pharmacological treatment for ≥ 6 weeks
• Able to understand and follow exercise instructions

You may not qualify if…

• Absolute contraindications to exercise (e.g., recent MI, unstable angina, uncontrolled arrhythmias, severe aortic stenosis, decompensated HF)
• Abnormal CPET findings (severe arrhythmias, ischemia, ST depression)
• Abnormal blood pressure response during exercise
• Exercise-induced angina or thoracic pain
• Musculoskeletal, neurological, or cognitive impairments limiting exercise participation

Where it is running

• community based Cardiac Rehab Unit, Cardiac Centers, and Tertiary Care Hospitals — Lahore, Punjab Province, Pakistan

Full record on ClinicalTrials.gov

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