Effects of High-Frequency Chest Wall Oscillation Combined With Concurrent Training on Cough,in Cystic Fibrosis Patients
Starting soon · Not applicable
Conditions studied: Cystic Fibrosis
In brief
This randomized clinical trial aims to evaluate the effects of high-frequency chest wall oscillation (HFCWO) combined with concurrent training on cough, sputum clearance, exercise tolerance, and respiratory muscle strength in patients with Cystic Fibrosis. A total of 24 participants meeting inclusion criteria will be randomly allocated into two groups: Group A will receive HFCWO plus concurrent training, while Group B will receive HFCWO alone for 8 weeks. Outcomes will be measured before and after intervention using the 6-minute walk test, spirometry, Leicester Cough Questionnaire, sputum volume, and the Cystic Fibrosis Questionnaire-Revised. The study will be conducted at Pulmonary Rehabilitation Unit, Gulab Devi Hospital and Mayo Hospital, Lahore. Statistical analysis will be performed using IBM SPSS Statistics, with significance set at p \< 0.05.
Key facts
- Study ID
- NCT07519460
- Run by
- Riphah International University
- People needed
- 24
- Starts
- 2026-04-01
- Expected to finish
- 2026-05-29
- Last updated by the study team
- 2026-04-09
Who can join
Age: 16 and older, up to 35. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosed with Cystic Fibrosis, confirmed by genotype or sweat chloride >60 mmol/L.
- Age 16-35 years.
- Both male and female participants.
- Stable clinical condition (no exacerbations in the last 2 weeks).
- Forced expiratory volume in 1 second (FEV₁ ≥ 20% predicted).
You may not qualify if…
- Active hemoptysis or pneumothorax.
- Risk of hemodynamic instability or severe hypoxia.
- Acute airway infection.
- Cognitive disorders affecting compliance.
- Pregnancy.
- Cardiac diseases such as heart failure or arrhythmias.
- Neurological or orthopedic illnesses or recent chest injury.
Where it is running
- Gulab Devi Hospital, Mayo Hospital Lahore. — Lahore, Punjab Province, Pakistan
Full record on ClinicalTrials.gov
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