Effect of Preoperative Oral Carbohydrate Loading on Postoperative Outcomes in Liver Transplant Patients

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Liver Transplantation, Liver Transplant, Liver Transplant Surgery, End Stage Liver Disease

In brief

The aim of the study is to evaluate the effect of preoperative oral carbohydrate loading on postoperative outcomes in liver transplant recipients. The results of this study may contribute to improving recovery after liver transplantation and shortening postoperative hospital stay in these patients. Participants will be randomly assigned to either the study group or the control group. Patients assigned to the study group will receive 400 mL of a carbohydrate beverage (Nutricia preOp®), to be consumed up to 2 hours before the anesthesia induction. Patients assigned to the control group will receive 400 mL of a placebo administered in an identical manner as in the study group. Participants will not be informed which group they have been assigned to. In the postoperative period, routine laboratory and imaging tests will be performed, and their results will be used to assess the effects of the intervention. Follow-up of the patient's clinical course is planned for up to 30 days after surgery. The schedule of follow-up visits will not differ from standard clinical practice.

Key facts

Study ID

NCT07519057

Run by

Medical University of Warsaw

People needed

434

Starts

2026-05-27

Expected to finish

2028-08-01

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age ≥ 18 years
• elective liver transplantation at the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw
• grafts from brain-dead donors
• MELD score <35

You may not qualify if…

• acute liver failure
• insulin-dependent diabetes mellitus
• gastroparesis
• mechanical bowel obstruction
• liver retransplantation within less than 6 months of the primary transplant

Where it is running

• Department of General, Transplant, and Liver Surgery, Medical University of Warsaw — Warsaw, Poland (enrolling)

Full record on ClinicalTrials.gov

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