Telemedicine-guided Uptitration of Therapy in Chronic Heart Failure
Recruiting now · Not applicable
Conditions studied: Heart Failure With Reduced Ejection Fraction (HFrEF)
In brief
This is a single-center, randomized, open-label, no-profit interventional trial designed to evaluate the effectiveness of a telemedicine-based follow-up strategy compared with standard ambulatory care in patients with newly diagnosed heart failure with reduced ejection fraction (HFrEF). The study aims to determine whether telemedicine-guided management improves the optimization of guideline-directed medical therapy (GDMT), measured as change in GDMT score at 6 months. Patients will be randomized to either a telemedicine group, involving remote multiparametric monitoring and structured teleconsultations, or a standard-of-care group based on conventional in-person follow-up. Secondary objectives include the assessment of safety, treatment adherence, quality of life, and heart failure-related urgent visits, emergency department access, and hospitalizations. This study will provide evidence on the role of telemedicine in facilitating early and effective optimization of heart failure therapy and improving clinical management in a real-world setting.
Key facts
- Study ID
- NCT07518030
- Run by
- Azienda Unita Sanitaria Locale di Piacenza
- People needed
- 80
- Starts
- 2026-03-20
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-05-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Ongoing treatment with two or more guideline-directed heart failure medications at the time of HFrEF diagnosis
- Presence of severe comorbidities or clinical instability requiring prolonged or continuous hospital management
- Estimated life expectancy <12 months
- Pregnancy or breastfeeding
Where it is running
- Clinical Research Office, AUSL Piacenza — Piacenza, Italy (enrolling)
Full record on ClinicalTrials.gov
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