Comparison of the Effects of Desflurane-Remifentanyl and Propofol-Remifentanyl Anesthesia on Intraoperative Cerebral Oxygenation in Patients Undergoing Laparoscopic Cholecystectomy

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Conditions studied: ıntraoperative Cerebral Oxygenation, Cerebral Oxygenation Monitoring

In brief

Study Population: Patients undergoing elective laparoscopic cholecystectomy under general anesthesia will be included. Study Design: This is an observational study. No interventions outside routine clinical practice will be applied. All procedures will be performed by experienced anesthesiologists according to standard institutional protocols. Data Collection Preoperative Data: The following variables will be recorded from anesthesia charts: Demographics: age, sex, height, weight, body mass index (BMI) Education level Smoking, alcohol, and substance use status Routine preoperative laboratory tests Clinical scores: Charlson Comorbidity Index (CCI) Beck Anxiety Scale ARISCAT Score STOP-BANG Score Montreal Cognitive Assessment (MoCA) ASA Physical Status Classification Intraoperative Data: Patients will be observed in two groups based on anesthesia technique: Desflurane + remifentanyl Total intravenous anesthesia (TIVA: propofol + remifentanyl) The following parameters will be recorded: Hemodynamic data: blood pressure, heart rate Oxygenation parameters: SpO₂, SpO₂/FiO₂ ratio Cerebral and depth monitoring: NIRS, BIS Respiratory mechanics Oxygen Saturation Index (OSI = \[Pmean × FiO₂\] / SpO₂) Mechanical ventilator parameters Time Points for Measurement: Before induction After induction After intubation Every 20 minutes intraoperatively After extubation Additional Intraoperative Variables: Duration of surgery and anesthesia Total anesthetic drug consumption: Desflurane and remifentanyl Propofol and remifentanyl (TIVA group) Intraoperative blood transfusion (yes/no) Total blood loss Urine output Recovery time Postoperative Follow-up ICU admission (planned or unplanned) Pain assessment using Numeric Rating Scale (NRS): PACU Postoperative 1st, 3rd, 6th, 12th, and 24th hours Postoperative Complications: Nausea and vomiting Hypotension Arrhythmia (bradycardia, tachycardia) Pulmonary edema Atelectasis Pneumonia Pneumothorax Pleural effusion Cognitive dysfunction Other Outcomes: Postoperative MoCA and Beck Anxiety Scale scores Length of hospital stay Length of ICU stay (if applicable) Mortality during follow-up

Key facts

Study ID: NCT07517146
Run by: Ankara Ataturk Sanatorium Training and Research Hospital
People needed: 84
Starts: 2026-04-06
Expected to finish: 2026-09-01
Last updated by the study team: 2026-04-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Those with ASA 1-2-3
Those who have undergone laparoscopic cholecystectomy
Those with BMI between 18-40 kg/m2

You may not qualify if…

Emergency surgeries
Individuals with neurological disorders, diseases, or drug (opioid or sedative) use that affect cognitive function
Individuals who do not speak Turkish
Individuals who have received general anesthesia within the last 7 days
Individuals with severe organ dysfunction
Individuals allergic to the drugs used in the study

Where it is running

Ankara Atatürk Sanatorium Training and Research Hospital — Ankara, Ankara, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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