PRISM-NLM: Prostatectomy Intraoperative Surgical Margin Assessment With Non-linear Microscopy

Starting soon · Not applicable

Conditions studied: Prostate Cancer

In brief

This study will evaluate the use of intraoperative nonlinear microscopy (NLM) for surgical margin assessment during nerve-sparing radical prostatectomy in participants with prostate cancer.

Key facts

Study ID

NCT07516808

Run by

Beth Israel Deaconess Medical Center

People needed

20

Starts

2026-06-01

Expected to finish

2027-08-28

Last updated by the study team

2026-04-08

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years old.
• Male or assigned male at birth (AMAB).
• Initial diagnosis of localized PrCa.
• Undergoing radical prostatectomy at BIDMC as part of their standard of care.

You may not qualify if…

• No short-form available in the participant's language.
• Cognitively unable to provide consent, in the opinion of the investigator.
• Patients with evidence of unequivocal radiologic bilateral extraprostatic extension (EPE) on most recent MRI results.
• Patients with >80 cc prostate volume (larger prostates would require potentially excessive evaluation time).

Where it is running

• Beth Israel Deaconess Medical Center (BIDMC) — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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