Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
Starting soon
Conditions studied: Sepsis and Septic Shock
In brief
This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using echocardiography (VTI) and cardiometry. We will correlate the changes in measuring cardiac output by both echocardiography and cardiometry with the changes in dynamic central venous oxygen saturation both at baseline and after fluid challenge to investigate the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock.
Key facts
- Study ID
- NCT07516236
- Run by
- Menoufia University
- People needed
- 115
- Starts
- 2026-04-01
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2026-04-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 18 years
- Diagnosis of septic shock according to Sepsis-3 criteria:
- Suspected or confirmed infection o Requirement for vasopressors to maintain MAP > 65 mmHg o Serum lactate > 2 mmol/L despite adequate fluid resuscitation
You may not qualify if…
- Pregnancy
- Significant valvular heart disease.
- Atrial fibrillation.
- Inadequate echocardiographic window.
- Ongoing bleeding or contraindication to fluid bolus.
Where it is running
- Menoufia University — Menouf, Egypt
Full record on ClinicalTrials.gov
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