Brain Connectivity and Corticospinal Excitability in Response to Moderate Hypoxia

Starting soon · Not applicable

Conditions studied: Normoxia, Intermittent Moderate Hypoxia, Continuous Moderate Hypoxia

In brief

Hypoxia, defined as a reduction in the availability of oxygen, induces significant physiological adaptations. While the deleterious effects of severe and chronic hypoxia are well documented, several studies indicate that moderate hypoxia - particularly when administered intermittently - may produce beneficial effects on cardiometabolic health (e.g., improved regulation of blood pressure and better glycaemic control). However, its impact on the dynamics of brain circuits in humans remains relatively underexplored. The present project aims to characterise the effects of continuous and intermittent moderate hypoxia on resting-state brain dynamics in healthy adults. To this end, simultaneous electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) recordings will be conducted in order to extract functional and haemodynamic markers of brain activity. This project will contribute to a better understanding of the neurophysiological mechanisms associated with hypoxic conditioning and to the assessment of its potential application in innovative therapeutic approaches.

Key facts

Study ID

NCT07516028

Run by

Universite du Littoral Cote d'Opale

People needed

36

Starts

2026-03-15

Expected to finish

2026-12-20

Last updated by the study team

2026-04-07

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female aged 18 to 65 years
• Healthy right- or left-handed individuals with no self-reported neurological disorders or history of neurological conditions (e.g., epilepsy, stroke, brain or spinal surgery, or neurological diseases affecting motor or sensory function such as multiple sclerosis, or neurodegenerative diseases such as Parkinson's or Alzheimer's)
• Individuals who have provided informed consent and have sufficient proficiency in French
• Participants affiliated with, or beneficiaries of, a social security scheme

You may not qualify if…

• Body mass index (BMI) greater than 30 kg/m²
• Diagnosed and untreated obstructive sleep apnoea syndrome
• Inability to provide informed consent
• History of cardiac (e.g., ischaemic heart disease, heart failure) and/or respiratory disorders (e.g., COPD, chronic respiratory insufficiency, persistent or uncontrolled asthma)
• Current smokers
• Contraindications to TMS (e.g., uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp lesions, elevated intracranial pressure, cerebrospinal fluid shunt)
• Use of psychotropic medication
• Individuals under legal guardianship or curatorship
• Pregnant or breastfeeding women
• Participants who have flown by air or travelled to terrestrial altitudes above 1500 metres within the seven days prior to inclusion

Where it is running

• Eurasport — Loos, Hauts-de-France, France

Full record on ClinicalTrials.gov

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