Supplemental Oxygen and Oxygen Desaturations in Colonoscopies

Starting soon · Not applicable

Conditions studied: Oxygen Desaturation, Apnea (Central and Obstructive), Airway Obstruction

In brief

This study will compare apnea and oxygen desaturation events among various methods of supplemental oxygen delivery during procedural sedation in colonoscopy patients. The goals of the study are to track apnea (10 or more seconds without respiration) and oxygen desaturation (hemoglobin oxygen saturation less than 90%) events in colonoscopy patients receiving one of three different methods of supplemental oxygen administration. The first method is standard-of-care continuous flow oxygen therapy, where a constant flow of oxygen is administered through a nasal cannula or oxygen mask. The second method is synchronized flow oxygen therapy. This is a delivery method implemented in an FDA-cleared medical device (Sovant, Dynasthetics LLC) which delivers variable-volume oxygen pulses only as the patient inhales. The delivered oxygen pulses are commensurate to the set flow rate and the patient's respiratory rate. The third method is continuous positive airway pressure therapy (CPAP), where non-invasive pressure support is given to the patient's airway to help keep their airway open. The hypothesis being tested is that synchronized flow delivery and CPAP therapy will demonstrate reductions in apnea and oxygen desaturation events compared to traditional continuous flow oxygen therapy.

Key facts

Study ID

NCT07515755

Run by

University of Utah

People needed

280

Starts

2026-05-18

Expected to finish

2026-12-31

Last updated by the study team

2026-04-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult patient
• No life threatening conditions
• Undergoing colonoscopy procedures and receiving procedural sedation at the University of Utah Health clinic in South Jordan, Utah.

You may not qualify if…

• Inability/refusal of subject to provide informed consent.
• Less than 18 years of age.
• Standard colonoscopy exclusion criteria used at the GI lab at the University of Utah.
• Patients known or suspected to be pregnant.
• Patients with an ASA physical status of IV (A patient with severe systemic disease that is a constant threat to life) or V (A moribund patient who is not expected to survive without the operation).
• Patients known to have acute respiratory distress syndrome, severe COPD, or cardiovascular disease.
• If their oxygen saturation measured by pulse oximetry (SpO2) is below 93% while breathing room air prior to the procedure.
• Patients with severe medical condition(s) that in the view of the acting physician prohibits participation in the study.

Where it is running

• University of Utah South Jordan Health Center - Endoscopy — South Jordan, Utah, United States

Full record on ClinicalTrials.gov

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