Vitamin K for Perioperative Warfarin Management

Recruiting now · Phase 4

Conditions studied: Anticoagulant Therapy

In brief

This is a feasibility study of uninterrupted warfarin with a one time dose of Vitamin K before a surgical procedure.

Key facts

Study ID

NCT07515664

Run by

University of Michigan

People needed

20

Starts

2025-07-03

Expected to finish

2026-08-01

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Warfarin therapy for ≥3 months
• Use of home INR testing equipment
• Scheduled for a surgical procedure that requires INR ≤ 1.5 (typically achieved with warfarin interruption)
• INR ≤ 4 on day 7-10 prior to procedure

You may not qualify if…

• Surgical procedure does not require INR ≤1.5 (typically achieved with warfarin interruption)
• Surgical procedure with a high risk of bleeding or complications (urologic procedures, bronchoscopy, epidural injections, nerve blocks, spinal surgery)
• Warfarin therapy for < 3 months
• Lack of English language proficiency
• Use of a Heartmate II or HVAD left ventricular assist device
• Recent thrombotic event (within 3 months)
• CHA2DS2-VASc score >6
• INR >4 on day 7-10 prior to procedure
• Hypersensitivity to any component of Vitamin K or simple syrup (used in the compounding process)

Where it is running

• Michigan Medicine — Ann Arbor, Michigan, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.