A Trial Investigating Lu AF28996 in Adults With Parkinson's Disease Who Have Motor Fluctuations

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Parkinson's Disease

In brief

This trial will evaluate the effects of Lu AF28996 in adults with Parkinson's disease (PD) experiencing motor fluctuations despite optimized non-invasive symptomatic treatment. These are individuals with PD who take medications to control movement symptoms, such as slowness, stiffness, and tremor, but still experience periods of time when their medication does not adequately control their motor symptoms. Some may also experience dyskinesia (other type of involuntary movements) as a side effect of their PD medications. The main goal of the trial is to learn whether adding Lu AF28996 to participants' optimized PD medications will help extending the time they spend with their movement symptoms being well-controlled and without bothersome dyskinesia.

Key facts

Study ID

NCT07514858

Run by

H. Lundbeck A/S

People needed

150

Starts

2026-06-30

Expected to finish

2028-12-30

Last updated by the study team

2026-04-07

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

Full record on ClinicalTrials.gov

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