Validation of a Regional Citrate Anticoagulation Protocol in Critically Ill Patients on Continuous Renal Replacement Therapy

Recruiting now · Not applicable

Conditions studied: Acute Kidney Injury, ICU Patients, Continuous Renal Replacement Therapy (CRRT), Electrolytes

In brief

The objective of this study is to evaluate the effectiveness of a modified continuous renal replacement therapy (CRRT) protocol in maintaining electrolyte balance in adult patients with acute kidney injury (AKI) admitted to the intensive care unit (ICU). The study assesses whether the use of continuous venovenous hemodiafiltration (CVVHDF) with post-filter replacement under citrate anticoagulation reduces electrolyte losses and the need for electrolyte supplementation compared with standard dialytic CRRT. Participants receiving standard CRRT will be compared with those treated with the modified protocol. The duration of participation corresponds to the period during which CRRT is required. Data collection will cease once CRRT is discontinued.

Key facts

Study ID

NCT07514650

Run by

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

People needed

43

Starts

2024-11-24

Expected to finish

2026-11-01

Last updated by the study team

2026-04-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Admission to the intensive care unit (ICU)
• Diagnosis of acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT)
• Use of regional citrate anticoagulation during CRRT Exclusion Criteria
• Known allergy or intolerance to citrate
• Contraindications to citrate anticoagulation (e.g., severe liver failure or severe metabolic disorders affecting citrate metabolism)
• Pregnancy or breastfeeding

Where it is running

• Hospital de la Santa Creu i Sant Pau — Barcelona, Barcelona, Spain (enrolling)

Full record on ClinicalTrials.gov

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