LISA vs Endotracheal Surfactant in Preterm Neonates: A Lung Ultrasound Distribution Study

Recruiting now · Not applicable

Conditions studied: Respiratory Distress Syndrome, Newborn

In brief

This prospective, non-randomized, unblinded pilot study evaluates and compares the intrapulmonary distribution of exogenous surfactant in preterm neonates when administered via Less Invasive Surfactant Administration (LISA) versus conventional endotracheal intubation (ETT). Lung ultrasound (LUS) will be utilized to assess the pioneer Surfactant Distribution Homogeneity Index (SDHI) to quantify the evenness and extent of surfactant-induced lung aeration. Secondary objectives include evaluating changes in LUS scores, short-term clinical respiratory outcomes, and feasibility parameters for guiding future larger-scale trials.

Key facts

Study ID

NCT07514481

Run by

Hamad General Hospital

People needed

22

Starts

2026-01-01

Expected to finish

2026-07-30

Last updated by the study team

2026-04-07

Who can join

Age: 0 and older, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Gestational age 24+0 to 42+6 weeks. Clinical and radiographic diagnosis of Respiratory Distress Syndrome (RDS). Requirement for surfactant within the first 3 days of life. Written informed parental consent.

You may not qualify if…

• Infants intubated at birth or who received surfactant prophylactically in the delivery room.
• Major congenital anomalies or lung malformations (e.g., congenital diaphragmatic hernia, pulmonary hypoplasia).
• Syndromic or genetic conditions affecting lung or chest wall development. Severe hemodynamic instability or congenital heart disease requiring intensive support.
• Lack of parental consent for trial participation.

Where it is running

• Women's Wellness and Research Center (WWRC), Hamad Medical Corporation — Doha, Qatar (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.