Examining Olive Oil Extract on Knee Comfort and Function

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Healthy Adult Male, Healthy Adult Females, Joint Discomfort

In brief

The goal of this study is to learn if an olive oil extract works to improve knee pain and discomfort in adults. The main questions it aims to answer are: 1) Does the olive oil extract improve the perceptions of knee pain and discomfort, and 2) Does the olive oil extract improve knee function in adults? The main procedures in the study include: * Screening and informed consent * Take one assigned study capsule (supplement or placebo) daily with food for 6 weeks * Complete digital questionnaires about your knee pain, stiffness, and function at scheduled times * Complete a Day 1 acute assessment and two simple functional movement tests at home as described below * If possible, connect a compatible wearable device to allow collection of sleep and physical activity data as detailed below. * Collect saliva samples at home using a provided kit at designated timepoints * Record any pain medications taken during the study or any side effects

Key facts

Study ID

NCT07514013

Run by

Applied Food Sciences Inc.

People needed

168

Starts

2026-04-01

Expected to finish

2026-11-01

Last updated by the study team

2026-04-15

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants must meet all of the following criteria to be eligible for participation:
• Adults aged 40 to 75 years
• Self-reported knee discomfort for at least 3 months
• Willing and able to take one study capsule daily for the duration of the study
• Willing and able to complete digital questionnaires, functional movement tasks, and other study activities using the Alethios platform
• Willing and able to wear a compatible activity-tracking device throughout the study
• Willing and able to collect saliva samples at home using a provided kit, if applicable
• Able to read and understand English
• Willing to provide informed consent electronically

You may not qualify if…

• Participants will be excluded if any of the following apply:
• Diagnosis of inflammatory joint disease (e.g., rheumatoid arthritis) or other systemic inflammatory conditions affecting the knee
• Any current or prior diagnosis from a licensed medical provider of knee disease
• Knee surgery or significant knee injury within the past 6 months
• Planned knee surgery during the study period
• Known allergy or sensitivity to olive-derived products or any component of the study product
• Current use of investigational drugs or participation in another research study during the study period
• Any medical condition or circumstance that, in the opinion of the investigator, would make participation unsafe or interfere with study participation or data quality

Where it is running

• Alethios, Inc. — San Francisco, California, United States (enrolling)

Full record on ClinicalTrials.gov

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