Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease

Recruiting now · Not applicable

Conditions studied: Huntington Disease

In brief

The purpose of this research study is to determine the optimal pulse repetition frequency of low-intensity focused ultrasound that is safe and effective in improving motor symptoms in patients with Huntington's disease.

Key facts

Study ID

NCT07513844

Run by

First Affiliated Hospital of Fujian Medical University

People needed

24

Starts

2026-04-20

Expected to finish

2027-03-31

Last updated by the study team

2026-04-29

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 to 75 years (inclusive)
• Genetically confirmed Huntington's disease with HTT CAG repeat length of 40 or greater
• Unified Huntington's Disease Rating Scale Total Maximal Chorea score of 8 or higher on a scale of 0 to 28, with higher scores indicating more severe chorea
• Huntington's Disease Integrated Staging System stage 2 or 3
• Willing to participate and provide informed consent
• Have a reliable caregiver available
• No severe cognitive impairment that would preclude reliable reporting of adverse events or efficacy during treatment

You may not qualify if…

• History of self-injury, aggressive behavior, or unstable psychiatric disorders
• History of head injury or neurosurgical procedure
• Presence of intracranial implants, metallic foreign bodies, cochlear implants, or cardiac pacemakers
• Severe systemic disease, pregnancy, or breastfeeding
• Contraindications to magnetic resonance imaging, ultrasound, or anesthesia
• Prior treatment with electroconvulsive therapy, transcranial magnetic stimulation, transcranial direct current stimulation, transcranial alternating current stimulation, or other neuromodulation therapies within the past 3 years
• Severe brain atrophy with unclear external globus pallidus structure on MRI
• Concurrent participation in another interventional clinical trial
• Any other condition that, in the opinion of the investigator, would preclude participation

Where it is running

• Department of Rehabilitation Medicine, The First Affiliated Hospital of Fujian Medical University — Fuzhou, Fujian, China (enrolling)

Full record on ClinicalTrials.gov

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