Vitamin C for Gingival Depigmentation
Recruiting now · Not applicable
Conditions studied: Gingival Hyperpigmentation, Gingival Melanin Pigmentation
In brief
The purpose of this study is to evaluate the clinical and histopathological efficacy of topical vitamin C applications using three modalities (topical gel, microneedling , and mesotherapy) in gingival depigmentation. Assessment includes clinical evaluation, CIELAB analysis via DOPI, and histopathological examination (Fontana-Masson staining).
Key facts
- Study ID
- NCT07513727
- Run by
- Al-Azhar University
- People needed
- 30
- Starts
- 2025-07-29
- Expected to finish
- 2026-05-01
- Last updated by the study team
- 2026-04-07
Who can join
Age: 20 and older, up to 40. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 1- Both genders aged from 20-35 years. 2- Patients clinically diagnosed with physiologic gingival melanin pigmentation in the maxillary and mandibular keratinized gingiva.
- 3- Patients complaining of compromised esthetics. 4- Patients should be systemically free any disease as verified by a medical history diagnostic sheet or via health questionnaire
You may not qualify if…
- 1- Patient clinically diagnosed with periodontitis and / or manifest poor oral hygiene with high plaque and gingival indices 2- Pregnant or lactating females. 3- Patients with clinical diagnosed lesion in the area of interest primarily the gingivae encompassing the maxillary /mandibular anterior teeth e.g. pigmented lesion of intestinal polyposis syndrome, McCune-Albright syndrome and fibro-osseous lesions as florid osseous dysplasia.
- 4- Patient with previous treatment of gingival hyperpigmentation. 5- Patients with history of being allergic to the vitamin C. 6- Patients with any systemic disease ( e.g. Addison disease ) or drugs consumed that may cause clinical gingival hyperpigmentation 7- Patients who are active or previous smokers.
Where it is running
- Al-Azhar University Faculty of Dentistry ( Girls ) — Cairo, Cario Governorate, Egypt (enrolling)
Full record on ClinicalTrials.gov
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