Autologous Exosomes From Platelet-rich Plasma as a Modern Tool of Regenerative Dentistry
Enrolling by invitation
Conditions studied: Temporomandibular Disorders (TMD), Muscle Pain, TMJ Pain
In brief
The aim of the research is the laboratory assessment of the content as well as the regenerative and anti-inflammatory potential of autologous exosomes (EXO) from platelet-rich plasma (PRP), as well as their comparison with other autologous products used in intra-articular injections, namely platelet-rich plasma and platelet-rich fibrin (PRF). The material for the research will be obtained from patients of the Temporomandibular Joint Dysfunction Clinic at the University Dental Center in Wrocław with chronic pain of the temporomandibular joints (TMJ) and/or masticatory muscles and/or chronic disturbances in temporomandibular joint mobility, as well as from healthy individuals. In the subsequent stages, the biological material will be analyzed under laboratory conditions to compare the composition and biological properties of PRP, PRF and EXO.
Key facts
- Study ID
- NCT07511959
- Run by
- Wroclaw Medical University
- People needed
- 68
- Starts
- 2026-05-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-07-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- chronic pain of the temporomandibular joints and/or masticatory muscles and/or chronic dysfunction of the temporomandibular joints (lasting more than 3 months, diagnosed based on the standardized, international Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol) - criterion for the study group
- consent to participate in the study - criterion for both groups
- age over 18 years - criterion for both groups
You may not qualify if…
- cancer,
- pregnancy
- uncontrolled diabetes
- cardiovascular diseases (platelet dysfunction syndrome, critical thrombocytopenia, hemodynamic instability, sepsis, hemoglobin < 10 g/dl, platelet count < 105/µl)
- severe autoimmune diseases
- taking anticoagulants
- active skin lesions at the planned puncture site
- infections, patient undergoing antibiotic therapy, or within 3 weeks of its completion.
Where it is running
- Wroclaw Medical Uniwesity, Wroclaw — Wroclaw, Poland
Full record on ClinicalTrials.gov
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