Stress-buffering and Sleep Disturbance-resilient Effects of a Dual Bifidobacterium Longum Combination Under Short-term Travel

Starting soon · Phase 2 · Has a placebo group

Conditions studied: Healthy

In brief

This study aims to evaluate the effects of a dual Bifidobacterium longum probiotic formulation (dipro-O and dipro-X) on sleep quality, stress responses, and gut microbiota stability in healthy adults during short-term travel. Using a randomized, double-blind, placebo-controlled design, the study investigates whether probiotic supplementation can enhance sleep resilience, buffer stress, and modulate microbiome and physiological responses under travel-related environmental changes.

Key facts

Study ID

NCT07511855

Run by

Min-Tze LIONG

People needed

60

Starts

2026-07-01

Expected to finish

2027-05-31

Last updated by the study team

2026-07-09

Who can join

Age: 25 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Willing to participate in this study and able to provide written informed consent before any study procedures are initiated.
• Able and willing to comply with all study procedures as required by the protocol, including continuous wearable device use, saliva and stool sample collection, and completion of questionnaire assessments.
• Willing to accept randomization and group allocation as determined by the study protocol.

You may not qualify if…

• Known use of antibiotics or systemic corticosteroids within 4 weeks prior to enrollment.
• Use of probiotic supplements within 4 weeks prior to enrollment.
• Planned use of any probiotic supplements during the study period.
• Known history or current presence of major endocrine disorders, active inflammatory bowel disease or other severe gastrointestinal diseases, or severe sleep disorders requiring treatment adjustment.
• Pregnant or intend to get pregnant, or lactating women.
• Known allergy to any probiotic products.
• Participation in any other clinical interventional study involving drugs, dietary supplements, probiotics, or prebiotics within the past three months.
• Or those who, according to the researcher's judgment, may have inadequate adherence or are unable to complete the study protocol.

Where it is running

• The Hong Kong Polytechnic University — Kowloon, Kowloon, Hong Kong

Full record on ClinicalTrials.gov

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