REST-Knee: A Pilot RCT of 72-Hour Knee Immobilization and Pain Outcomes
Recruiting now · Not applicable
Conditions studied: Total Knee Arthroplasty
In brief
Postoperative pain following total knee arthroplasty (TKA) is often difficult to manage, particularly with the increasing use of outpatient surgery where patients recover at home. This study aims to evaluate whether wearing a knee extension brace for the first 72 hours after surgery can reduce pain and improve recovery. This pilot randomized controlled trial will compare two groups of patients undergoing primary unilateral TKA: one group will wear an extension brace continuously for 72 hours after surgery, while the control group will follow standard care with early mobilization. Participants will be followed for up to 12 months. The primary objective of this pilot study is to assess the feasibility of conducting a larger trial, including recruitment rates, adherence to the intervention, follow-up completion, safety, and acceptability. Clinical outcomes will also be explored, including pain at 2 and 6 weeks after surgery (measured using a visual analog scale), knee function, range of motion, opioid consumption, complications, healthcare use, and quality of life. The study hypothesizes that short-term immobilization of the knee in full extension will reduce postoperative pain and may improve early recovery outcomes. Findings from this pilot study will inform the design of a larger definitive trial and may contribute to improving postoperative care and pain management after knee replacement surgery.
Key facts
- Study ID
- NCT07511842
- Run by
- Université de Sherbrooke
- People needed
- 106
- Starts
- 2026-03-03
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-04-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Person undergoing primary unilateral TKA for knee osteoarthritis at CHUS
You may not qualify if…
- Known thrombophilia or bleeding disorders
- History of thromboembolic events
- Contraindications to brace use (e.g., material allergy)
- Revision or constrained knee prostheses
- Use of continuous postoperative nerve block infusion
Where it is running
- CIUSSS de l'Estrie-CHUS, 3001, 12e Ave Nord, Sherbrooke, Qc, Canada, J1H 5N4 — Sherbrooke, Quebec, Canada (enrolling)
Full record on ClinicalTrials.gov
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