The Study Tests if Preoperative Dental Screening is Superior to no Preoperative Dental Screening in Improving the Outcome of Patients Undergoing Surgical Cardiac Valve Replacement or Transcatheter Cardiac Valve Implantation.

Recruiting now · Not applicable

Conditions studied: Infective Endocarditis (IE), Heart Valve Disease

In brief

This randomized, multicenter, open-label trial evaluates whether preoperative dental screening improves outcomes in patients undergoing surgical or transcatheter cardiac valve intervention. Participants are randomized 1:1 to preoperative dental screening or no screening. The primary outcome is time to first occurrence of all-cause death, redo-intervention of the index valve, or definite infective endocarditis within 2 years. The study uses registry-based follow-up to ensure complete outcome ascertainment.

Key facts

Study ID

NCT07511673

Run by

Region Skane

People needed

1300

Starts

2026-05-06

Expected to finish

2036-12-01

Last updated by the study team

2026-05-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Accepted for cardiac valve intervention
• Able to provide informed consent

You may not qualify if…

• Previous or ongoing infective endocarditis
• Urgent surgery
• Pain from loose tooth/teeth
• Immunosuppressive therapy (excluding corticosteroids)
• Inability to provide informed consent
• Expected loss to follow-up

Where it is running

• Skane University Hospital — Lund, Sweden (enrolling)
• Sahlgrenska University Hospital — Gothenburg, Sweden
• Linköping University Hospital — Linköping, Sweden
• Örebro University Hospital — Örebro, Sweden
• Karolinska University Hospital — Stockholm, Sweden

Full record on ClinicalTrials.gov

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