Comparison of Sevoflurane and Desflurane on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study
Starting soon · Not applicable
Conditions studied: General Anesthesia
In brief
This prospective randomized controlled study will compare the effects of sevoflurane and desflurane on the Analgesia Nociception Index (ANI) in adult patients undergoing general anesthesia. Participants will be randomized to maintenance anesthesia with either sevoflurane or desflurane, and ANI responses to a standardized nociceptive stimulus will be measured under equi-minimum alveolar concentration (age-adjusted 1.0 MAC) conditions. The primary objective is to compare the change in ANI before and after tetanic stimulation between the two anesthetic groups. Secondary measurements will include bispectral index, blood pressure, heart rate, and end-tidal anesthetic concentration around the time of stimulation.
Key facts
- Study ID
- NCT07511634
- Run by
- Pusan National University Yangsan Hospital
- People needed
- 80
- Starts
- 2026-04-01
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-04-06
Who can join
Age: 19 and older, up to 79. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 19 to 79 years
- Patients undergoing general anesthesia
- American Society of Anesthesiologists (ASA) physical status I or II
You may not qualify if…
- History of taking medications that may affect the central nervous system or autonomic nervous system (e.g., anticholinergics, beta-blockers, antidepressants, anxiolytics, hypnotics, or analgesics)
- Known hypersensitivity to sevoflurane, desflurane, or other halogenated anesthetics, or a personal or family history of malignant hyperthermia
- Neurologic or psychiatric disorders (e.g., depression, dementia, or cerebral infarction)
- Arrhythmia
- Diabetes mellitus
- Drug abuse or alcohol abuse
- Vulnerable subjects
- Patients aged 80 years or older
- Patients with impaired consciousness or those judged to lack the capacity to provide informed consent
Where it is running
- Pusan National University Yangsan Hospital — Yangsan, Gyeongsangnam-do, South Korea
Full record on ClinicalTrials.gov
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