Angiography-Derived Physiological Indices for Outcome Prediction in Patients Undergoing OCT-Guided PCI
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Conditions studied: Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
In brief
The primary design of this study is an ambispective observational cohort study. In patients undergoing successful optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) with post-procedural angiographic images suitable for computational analysis, this study aims to evaluate the prognostic value of post-PCI angiography-derived physiological indices, specifically angiography-derived fractional flow reserve (Angio-FFR) and angiography-derived index of microcirculatory resistance (Angio-IMR), beyond conventional clinical risk factors and OCT-derived anatomical parameters. Specifically, the objectives are: 1. To determine the associations of post-PCI Angio-FFR and Angio-IMR with the risk of Major Adverse Cardiovascular Events (MACE) during follow-up. 2. To evaluate the incremental prognostic value of post-PCI Angio-FFR and Angio-IMR when added to models incorporating baseline clinical characteristics and OCT-derived anatomical parameters for predicting MACE. 3. To assess whether the combined evaluation of Angio-FFR and Angio-IMR improves identification of residual risk after anatomically optimized, OCT-guided PCI.
Key facts
- Study ID
- NCT07511231
- Run by
- Beijing Anzhen Hospital
- People needed
- 1800
- Starts
- 2026-04-01
- Expected to finish
- 2029-07-01
- Last updated by the study team
- 2026-04-06
Who can join
Age: 18 and older, up to 84. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Beijing Anzhen Hospital, Capital Medical University — Beijing, China
Full record on ClinicalTrials.gov
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