AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Obesity, Overweight, Osteoarthritis, Knee
In brief
This study is being done to look at the safety and effect of NNC0487-0111 in people with excess body weight and knee osteoarthritis when compared to placebo. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111, (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.
Key facts
- Study ID
- NCT07509307
- Run by
- Novo Nordisk A/S
- People needed
- 400
- Starts
- 2026-04-20
- Expected to finish
- 2028-08-14
- Last updated by the study team
- 2026-07-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- First Valley Medical Group — Lancaster, California, United States (enrolling)
- MC Dr. Atanasov EOOD — Sofia, Bulgaria (enrolling)
- Chase Medical Research LLC — Waterbury, Connecticut, United States (enrolling)
- Westside Center For Clinical Research — Jacksonville, Florida, United States (enrolling)
- Desert Oasis Healthcare — Palm Springs, California, United States (enrolling)
- Neighborhood Healthcare — Escondido, California, United States (enrolling)
- Clinical Investigation Spec Gurnee — Gurnee, Illinois, United States (enrolling)
- Evanston Premier Hlthcr Res — Skokie, Illinois, United States (enrolling)
- Monroe Biomedical Research, LLC — Louisville, Kentucky, United States (enrolling)
- Arcturus Healthcare, PLC. — Troy, Michigan, United States (enrolling)
- Clinvest Research — Springfield, Missouri, United States (enrolling)
- Clinical Neuroscience Solutions, Inc. — Jacksonville, Florida, United States (enrolling)
- Advanced Res for Health Improve — Naples, Florida, United States (enrolling)
- Piedmont Healthcare/Research — Statesville, North Carolina, United States (enrolling)
- Northwest Research Center — Portland, Oregon, United States (enrolling)
- Mercy Family Clinic — Dallas, Texas, United States (enrolling)
- Health Res of Hampton Roads — Newport News, Virginia, United States (enrolling)
- Northwest Clinical Research Center — Bellevue, Washington, United States (enrolling)
- Emeritus Research Sydney — Botany, New South Wales, Australia (enrolling)
- Momentum Clinical Research Darlinghurst — Darlinghurst, New South Wales, Australia (enrolling)
- Kolling Institute — St Leonards, New South Wales, Australia (enrolling)
- Heart of Australia — Chelmer, Queensland, Australia (enrolling)
- Coastal Digestive Health — Maroochydore, Queensland, Australia (enrolling)
- UMHAT Sveti Georgi EAD, Plovdiv — Plovdiv, Bulgaria (enrolling)
- MC Excelsior OOD — Sofia, Bulgaria (enrolling)
Full record on ClinicalTrials.gov
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