Effect Of Electroacupuncture With Local Anesthesia On Pain And Stress During Impacted Lower Third Molar Surgery
Starting soon · Not applicable · Has a placebo group
Conditions studied: Postoperative Pain, Stress, Psychological, Impacted Lower Third Molar
In brief
This randomized controlled trial investigates the effect of electroacupuncture as an adjunct to local anesthesia on perioperative pain and stress during ambulatory surgical extraction of impacted lower third molars. Participants will be randomized into three groups: electroacupuncture, sham acupuncture, and control. Pain intensity and perceived stress will be assessed using validated scales, while biological stress and nociceptive markers (salivary cortisol, alpha-amylase, and substance P), as well as hemodynamic parameters (blood pressure and heart rate), will be measured. The study aims to provide an integrated evaluation of the effects of electroacupuncture on subjective, biological, and physiological indicators of perioperative response in oral surgery.
Key facts
- Study ID
- NCT07509294
- Run by
- University of Zagreb
- People needed
- 60
- Starts
- 2026-04-20
- Expected to finish
- 2026-12-18
- Last updated by the study team
- 2026-04-03
Who can join
Age: 25 and older, up to 35. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults aged 25-35 years
- ASA physical status I-II
- Indication for ambulatory surgical extraction of an impacted lower third molar
- Ability to understand the study procedures and provide written informed consent
- Willingness to comply with study procedures, including saliva sampling protocol
- Ability to abstain from food, beverages, and oral hygiene procedures for at least 1 hour prior to saliva sampling
You may not qualify if…
- Pregnancy
- Epilepsy
- Presence of a pacemaker or other active electronic implant
- Coagulation disorders
- Active infection at the site of acupuncture
- Systemic inflammatory diseases
- Oral inflammatory conditions (e.g., gingivitis or periodontitis)
- Hyposalivation
- Chronic opioid use
- Psychiatric conditions that may affect pain or stress assessment
- Use of nonsteroidal anti-inflammatory drugs, corticosteroids, or antibiotics within 7 days prior to the procedure
- Menstruation at the time of saliva sampling
- Inability or unwillingness to comply with study procedures
Where it is running
- University Hospital Dubrava — Zagreb, Croatia
Full record on ClinicalTrials.gov
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