ScvO2-Centered Optimisation of RED Blood Cell Transfusions
Starting soon · Not applicable
Conditions studied: Anaemia
In brief
This clinical trial aims to personalise red blood cell transfusion strategies in the crtitically ill patients. The amount of transfusions needs to be minimised in order to prevent adverse events and organ dysfunctions linked to high amounts of red blood cell transfusions. The researchers aim to investigate the efficacy and safety of measuring the central venous oxygen saturation (ScvO2) (oxygen content in a venous blood sample taken from a central line) to guide clinicians if transfusion is necessary. The researchers aim to compare the ScvO2 guided transfusion strategy with transfusion based on the clinician's judgment (taking into consideration the patients' comorbidities and actual vital parameters).
Key facts
- Study ID
- NCT07509203
- Run by
- Semmelweis University
- People needed
- 600
- Starts
- 2026-04-15
- Expected to finish
- 2029-04-01
- Last updated by the study team
- 2026-04-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient in medical/surgical/trauma ICU
- Hemoglobin level between 7g/dl and 9g/dl
- Written informed consent by patient or next of kin
- Hemodynamically stable:
- CRT normal
- Serum lactate <2 mmol/l
- MAP >65 mmHg
- noradrenalin < 0,2 mcg/kg/min and no increase in 6 hours
- No new ischemic change on ECG
- Monitored with CVC, arterial catheter, hourly urine output
- Respiratorily stable
- No support or
- Nasal canula/face mask O2 supplementation or
- NIV or
- Invasive mechanical ventillation: PC/VC/PS, PEEP< 15 cmH2O FiO2 < 50% and no increase in 6 hours
- PiCCO or expert ECHO available within 48hours
You may not qualify if…
- ScvO2>80%
- Acid-base imbalance (pH<7.3 or pH>7.5)
- Chronic kidney disease (KDIGO Stage 3-4-5)
- Acute heart failure (ESC 2021 definition)
- Pregnancy
- Active bleeding
- Neurotrauma requiring intracranial pressure monitoring
- Morbid obesity BMI >40
- Horowitz Quotient (paO2/FiO2) < 200
- Acute and chronic liver failure (Child-Pugh B,C)
- Fever
Where it is running
- Semmelweis University, Department of Intensive Therapy — Budapest, Hungary
- North-Pest Central Hospital- Hungarian Defense Forces Medical Center, Department of Anaesthesiology and Intensive Therapy — Budapest, Hungary
Full record on ClinicalTrials.gov
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