Effects of Brief Nature Exposure on Brain Functioning and Stress Reactivity

Completed

Conditions studied: Stress (Psychology)

In brief

This study is focused on understanding the impact of time spent in nature (relative to an urban control) on stress, neural, and cardiac functioning in people experiencing high levels of stress, depression, and anxiety.

Key facts

Study ID

NCT07508800

Run by

National Institutes of Health (NIH)

People needed

4

Starts

2026-01-01

Expected to finish

2026-06-30

Last updated by the study team

2026-07-23

Who can join

Age: 18 and older, up to 25. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets cut-off for high level of perceived stress on PSS-10 during screening (>27 total score); Current or past depressive and anxiety disorders, if present on SCID-5 assessment, will be ncluded due to their high prevalence and overlap with perceived stress
• Normal, or corrected to normal, vision (due to the visual nature of the EEG tasks)
• If on psychotropic medication, stable regime for > 1 month

You may not qualify if…

• Major medical conditions with CNS sequelae (e.g., seizure disorders, multiple sclerosis, significant, uncontrolled cardiovascular pathology) Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)
• IQ estimate <75 on the Test of Premorbid Functioning
• Current or past history of severe mental illness (e.g., bipolar schizophrenia spectrum disorder, or current or past history of substance use disorders

Where it is running

• University of San Francisco California OR San Francisco VA Medical Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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