Triple vs Dual Lipid-Lowering Therapy for LDL-C Reduction in Acute Coronary Syndrome

Starting soon · Phase 4

Conditions studied: Acute Coronary Syndromes (ACS), Hypercholesterolemia

In brief

The goal of this clinical trial is to evaluate whether triple lipid-lowering therapy (atorvastatin, ezetimibe, and bempedoic acid) is more effective than dual therapy (atorvastatin and ezetimibe) in reducing LDL cholesterol levels in adults with acute coronary syndrome. It will also assess the safety of the treatment. The main questions it aims to answer are: * Does triple therapy result in greater reduction in LDL-C compared to dual therapy? * What adverse effects occur in participants receiving triple therapy? Researchers will compare triple therapy to dual therapy to determine its effectiveness in lowering LDL-C levels. Participants will: * Receive either dual or triple lipid-lowering therapy for 3 months * Attend regular follow-up visits for clinical assessment and laboratory testing * Undergo lipid profile evaluation at baseline and at the end of the study

Key facts

Study ID

NCT07508254

Run by

Punjab Institute of Cardology

People needed

120

Starts

2026-05-01

Expected to finish

2026-10-31

Last updated by the study team

2026-04-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must be older than 18 years, male or female.
• Diagnosis of ACS (Acute Coronary Syndrome) is confirmed when hospitalized.
• Eligible for high-intensity statin therapy (atorvastatin)
• Patients can provide written informed consent.
• Patients will be eager to cooperate with study drugs and follow-up visits.

You may not qualify if…

• Intolerance or hypersensitivity to study drugs.
• Liver or ALT/AST greater than three times the upper normal.
• Renal dysfunction: estimated glomerular filtration rate (eGFR) less than 30 mL/min/1.73 m².
• Gout with frequent bouts or severe hyperuricemia.
• Pregnancy/lactation

Where it is running

• Punjab Institute of Cardiology — Lahore, Punjab Province, Pakistan

Full record on ClinicalTrials.gov

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