Probiotics for Constipation Relief in Adults
Starting soon · Not applicable · Has a placebo group
Conditions studied: Functional Constipation
In brief
This study aims to evaluate the efficacy and safety of Bifidobacterium animalis subsp. lactis BLa36 in adults with functional constipation. In this randomized, double-blind, placebo-controlled trial, participants will receive BLa36 supplementation or placebo for 8 weeks. Clinical outcomes will be assessed using validated gastrointestinal symptom scales, stool characteristics, and quality-of-life measures. In addition, changes in inflammatory and immune markers, gut microbiota composition, metabolic indicators, and gut-brain axis-related parameters will be evaluated to comprehensively determine the effects of BLa36 on intestinal function and overall health.
Key facts
- Study ID
- NCT07507955
- Run by
- Wecare Probiotics Co., Ltd.
- People needed
- 105
- Starts
- 2026-06-10
- Expected to finish
- 2027-01-20
- Last updated by the study team
- 2026-06-09
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 18-65 years;
- Individuals diagnosed with constipation, defined as fewer than 3 bowel movements per week and/or Bristol Stool Form Scale (BSFS) types 1-2;
- Able and willing to comply with all study procedures and complete the study;
- Provided written informed consent prior to participation;
- Participants (including males) must have no intention of conception from 14 days before screening until 6 months after study completion and agree to use effective contraception.
You may not qualify if…
- Recent use of products with similar effects that may interfere with study outcomes; Significant dietary changes during the study period;
- History of severe allergy or immunodeficiency;
- Pregnant or breastfeeding women, or those planning pregnancy;
- Presence of serious systemic diseases (e.g., cardiovascular, pulmonary, hepatic, renal, endocrine, or malignant conditions);
- Use of antibiotics within the past 2 weeks;
- Individuals with severe psychiatric or neurological disorders;
- Poor compliance, including failure to take the study product or attend scheduled visits;
- Any other condition deemed unsuitable by the investigator.
Where it is running
- Suzhou Ninth People's Hospital — Suzhou, Jiangsu, China
Full record on ClinicalTrials.gov
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