Low Versus Standard Volume EXORA Block in Laparoscopic Cholecystectomy

Starting soon · Not applicable

Conditions studied: Pain, Postoperative, Post Operative Analgesia

In brief

The original EXORA block used high local anesthetic volume (50 mL total), raising concerns about local anesthetic systemic toxicity (LAST). In such a bilaterally administered regional technique, evaluating the efficacy of a reduced-volume approach is warranted to maximize patient safety.

Key facts

Study ID

NCT07507799

Run by

Fayoum University Hospital

People needed

96

Starts

2026-04-10

Expected to finish

2026-11-02

Last updated by the study team

2026-04-16

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists (ASA) physical status I or II.
• Scheduled for elective laparoscopic cholecystectomy under general anesthesia.

You may not qualify if…

• • Patient refusal to participate.
• Obese patients with a body mass index of more than 35 kg/m2.
• Known cognitive impairment or use of psychiatric drugs
• Known allergy to local anesthetics
• Infection at the needle insertion site.
• Coagulopathy, or bleeding disorders.
• Pregnancy
• History of chronic pain or chronic opioid use.
• Previous major upper abdominal surgery (which alters the fascial planes and anatomy).
• Criteria for Withdrawal from Study Analysis (Drop-outs):
• Conversion to open cholecystectomy during surgery.
• Failed EXORA block

Where it is running

• Fayoum University hospital — El Fayoum Qesm, Faiyum Governorate, Egypt

Full record on ClinicalTrials.gov

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