A Study of Methylprednisolone in People Having Liver Surgery

Recruiting now · Phase 3

Conditions studied: Hepatectomy

In brief

The purpose of this study is to test whether receiving methylprednisolone before surgery will reduce the side effects of having surgery, such as infections and longer hospital stays.

Key facts

Study ID

NCT07507643

Run by

Memorial Sloan Kettering Cancer Center

People needed

750

Starts

2026-03-27

Expected to finish

2029-03-27

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years at the time of consent.
• Scheduled to undergo elective major hepatectomy (defined by CPT codes 47122 [trisegmentectomy], 47125 [total left hepatectomy], or 47130 [total right hepatectomy]).
• In addition to major hepatectomy, as defined above, patients may undergo additional partial hepatectomy or operative ablation.

You may not qualify if…

• Known or documented adverse reactions to methylprednisolone.
• Unable to receive methylprednisolone because of coexisting medical conditions.
• Long-term (≥10-day course) systemic corticosteroid use, regardless of dose, if doses have been administered within 30 days of the planned date of surgery. This will not apply to steroids administered, in accordance with the standard of care, with preoperative chemotherapy. The following uses of corticosteroids are permitted: single doses, topical applications (e.g., for rash), inhaled sprays (e.g., for obstructive-airway diseases), eye drops, and local injections (e.g., intra-articular).
• Significant chance (based on surgeon judgement) of being unable to successfully complete surgery because of unresectability.
• Expected or highly likely to undergo concomitant major organ resection (stomach, pancreas, colon, rectum, uterus, ovaries, bladder, kidney, small bowel).
• Expected or highly likely to undergo biliary tree reconstruction via creation of a biliary-enteric anastomosis.
• Scheduled to undergo concurrent insertion of a hepatic artery infusion pump device.
• Estimated renal dysfunction defined by any of the following: creatinine clearance
• ≤40 mL/min as calculated by the Cockcroft-Gault Equation, currently on hemodialysis, currently on peritoneal dialysis.
• Dependence on mechanical ventilation before surgery.
• Pregnant or nursing (lactating), where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test.
• Known at the time of enrollment to have a bacterial infection that is expected to be present at the time of surgery or receipt of systemic antibiotic or antifungal therapy within 7 days before surgery.
• Unable to provide informed consent

Where it is running

• Memoral Sloan Kettering Westchester (Data Collection Only) — Harrison, New York, United States (enrolling)
• Memorial Sloan Kettering Cancer Center (All Protocol Activities) — New York, New York, United States (enrolling)
• Memorial Sloan Kettering Commack (Data Collection Only) — Commack, New York, United States (enrolling)
• UNIVERSITY OF IOWA (Data Collection Only) — Iowa City, Iowa, United States
• University of Kentucky (Data Collection Only) — Lexington, Kentucky, United States
• Henry Ford Hospital (Data collection only) — Detroit, Michigan, United States
• Mayo Clinic (Data Collection Only) — Rochester, Minnesota, United States
• Washington University (Data Collection Only) — St Louis, Missouri, United States
• University of Nebraska Medical Center (Data Collection Only) — Omaha, Nebraska, United States
• Rutgers University (Data Collection Only) — New Brunswick, New Jersey, United States
• Northwell Health (Data collection only) — Manhasset, New York, United States
• New York University (Data Collection Only) — New York, New York, United States
• SUNY Upstate Medical University — Syracuse, New York, United States
• Duke University (Data Collection Only) — Durham, North Carolina, United States
• Gundersen Lutheran Medical Foundation (Data Collection Only) — La Crosse, Wisconsin, United States
• Rush University Medical Center (Data collection only) — Chicago, Illinois, United States
• University of Wisconsin (Data Collection Only) — Madison, Wisconsin, United States
• University of Chicago (Data Collection Only) — Chicago, Illinois, United States
• Indiana University (Data Collection Only) — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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