Performance of the Treatment of Periodontitis According to the Bioperio® Protocol

Recruiting now

Conditions studied: Periodontitis

In brief

This multicenter, prospective, single-arm observational study evaluated the clinical performance of the Bioperio® protocol, a standardized, patient-centered framework for managing periodontitis. The protocol combined professional supra-gingival scaling, oral hygiene instruction and motivation, full-mouth subgingival instrumentation, and-in Stage III/IV cases-adjunctive enamel matrix derivative application in deep pockets.

Key facts

Study ID

NCT07507474

Run by

University of Pisa

People needed

5000

Starts

2023-12-05

Expected to finish

2030-12-05

Last updated by the study team

2026-05-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Confirmed diagnosis of periodontitis (proximal attachment loss in ≥2 non-adjacent teeth)
• No previous treatment for periodontitis
• Systemically healthy or with well-controlled chronic medical conditions
• Willingness to participate in the study and comply with the follow-up schedule

You may not qualify if…

• Pregnancy or breastfeeding
• Patients previously treated for periodontitis
• Poorly controlled systemic conditions
• Refusal to participate
• Patients who did not complete the proposed treatment plan

Where it is running

• University of Pisa — Pisa, None Selected, Italy (enrolling)

Full record on ClinicalTrials.gov

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