Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults

Starting soon · Not applicable

Conditions studied: HIV, Inhaled Corticosteroid, Proton Pump Inhibitor, Smoking Cessation, Pneumonia

In brief

People with HIV (PWH) continue to experience elevated risk of community-acquired pneumonia despite effective antiretroviral therapy. Pneumonia contributes to hospitalization, respiratory failure, cardiovascular complications, long-term decline in lung function, and mortality. Several modifiable factors increase this risk, including active smoking, inadequate receipt of respiratory vaccinations, and inappropriate or prolonged use of inhaled corticosteroids (ICS) or proton-pump inhibitors (PPIs). OPTIMIZE Lung-HIV is a multicenter, patient-level randomized controlled hybrid Type 1 effectiveness-implementation trial evaluating whether a proactive, pharmacist-led E-consult intervention can improve evidence-based pulmonary pharmacotherapy for PWH. Pharmacists will review electronic health records, generate tailored recommendations, and pre-enter orders related to smoking cessation pharmacotherapy, vaccinations, and deprescribing of ICS or PPIs. Providers may enact or modify recommendations as clinically appropriate. The trial will assess the proportion of recommendations enacted within 3 months (primary outcome) and at 12 months (maintenance) and will use mixed methods guided by CFIR and RE-AIM to evaluate adoption, feasibility, acceptability, and implementation barriers and facilitators.

Key facts

Study ID

NCT07507435

Run by

Seattle Institute for Biomedical and Clinical Research

People needed

480

Starts

2026-08-01

Expected to finish

2029-09-01

Last updated by the study team

2026-07-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• PWH on ART for 6 months, receiving care at the VA, and one or more of the following:
• Actively smoking
• Prescribed ICS for >90 days
• Prescribed a PPI for >90 days

You may not qualify if…

• Enrolled in palliative care or hospice
• if a non-VA provider is the main primary care or HIV provider
• Are currently participating in a separate ongoing interventional clinical trial

Where it is running

• Boise VA Medical Center — Boise, Idaho, United States
• Minneapolis VA Health Care System — Minneapolis, Minnesota, United States
• VA Puget Sound Health Care System — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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