Simplified Exercise-based Risk Assessment in Lung Cancer

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Conditions studied: Lung Cancer (Diagnosis), Lobectomy, Surgery Complications, Neoadjuvant Chemoimmunotherapy, End-Tidal Carbon Dioxide, Exercise

In brief

Physiological evaluation is part of the preoperative risk estimation in patients with lung cancer, and it aids in the choice of treatment. Ventilatory efficiency during exercise has emerged as a strong predictor of major postoperative complications, so far determined during a maximal cardiopulmonary exercise test. However, this test is limited by its availability and high cost, due to the requirement of high-technological equipment and advanced expertise. The current project aims to evaluate a simplified and accessible method for risk evaluation before decision on treatment in lung cancer. It builds on recent advances in technology and knowledge and combines a simple, low-intensity cycling test with measurement of ventilatory efficiency (end-tidal carbon dioxide pressure) with a handheld monitor. In a prospective, multi-center design the investigators will include patients evaluated for suspected lung cancer. The main objective is to establish threshold values for end-tidal carbon dioxide associated with low respectively high risk of major complications in patients undergoing surgery. In addition, the study aims to determine if end-tidal carbon dioxide can predict severe side-effects during neoadjuvant or curatively aiming systemic therapy. The project is closely linked to clinical practice, and the results can be easily implemented due to the simple and cost-efficient methodology. the suggested simplified approach would also allow access to physiological evaluation where more advanced methods are unavailable.

Key facts

Study ID

NCT07506889

Run by

Linkoeping University

People needed

500

Starts

2026-04-01

Expected to finish

2029-12-01

Last updated by the study team

2026-04-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Lung Cancer Diagnosis
• Age of at least 18 years

You may not qualify if…

• Not able to perform cycle ergometer exercise
• Not able to understand spoken or written Swedish

Where it is running

• Department of Pulmonology, Ryhov — Jönköping, Sweden
• Department of Pulmonology, Kalmar County Hospital — Kalmar, Sweden
• Department of Pulmonology, Blekinge Hospital — Karlskrona, Sweden
• Department of Pulmonology, University Hospital — Linköping, Sweden
• Department of Clinical Physiology — Lund, Sweden

Full record on ClinicalTrials.gov

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