Concurrent Neoadjuvant Chemo/Endocrine Therapy in HER2+ Breast Cancer
Recruiting now · Phase 2
Conditions studied: Breast Cancer - Infiltrating Ductal Carcinoma, HER-2 Positive Breast Cancer
In brief
The usual approach to care for hormone receptor positive, HER2 positive breast cancer is chemotherapy and HER2 targeted therapy followed by endocrine therapy and surgery. The purpose of this Research Study is to see if taking endocrine therapy with the chemotherapy and HER2 directed therapy increases patients response to therapy at the time of surgery
Key facts
- Study ID
- NCT07506876
- Run by
- Legacy Health System
- People needed
- 30
- Starts
- 2026-04-27
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-05-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adults over 18 years of age with newly diagnosed, previously untreated, HR+, HER2+ breast cancer (positive per local guidelines)
- Endocrine therapy for the current breast cancer may be started within 28 days prior to trial enrollment and must be initiated prior to C2 of chemotherapy/HER2 directed therapy
- Choice of endocrine therapy will be determined by the treating and/or enrolling physician
- Anatomic Stage IIA - IIIC breast cancer planning a minimum of 4 cycles of TCHP
- Patients must be Luminal A, Luminal B or HER2 enriched subtype on MammaPrint/BluePrint performed on initial biopsy
You may not qualify if…
- Children under 18 years of age, pregnant women, prisoners, and decisionally impaired adults.
- Patients with non-breast cancer within prior 2 years
- Patients with breast cancer within prior 5 years
- Patients with recurrent breast cancer
- Patients with stage IV breast cancer
Where it is running
- Legacy Mount Hood Medical Center — Gresham, Oregon, United States (enrolling)
- Legacy Good Samaritan Medical Center — Portland, Oregon, United States (enrolling)
- Legacy Meridian Park Medical Center — Tualatin, Oregon, United States (enrolling)
- Legacy Salmon Creek Medical Center — Vancouver, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.