Pre-etched Bioactive Versus Resin- Based Fissure Sealant for Permanent Molars Affected With Molar Incisor Hypomineralization (MIH): a Randomized Clinical Trial

Enrolling by invitation · Not applicable

Conditions studied: Molar Incisor Hypomineralization, Fissure Sealant

In brief

This study aims to evaluate and compare the clinical performance of pre-etched bioactive fissure sealants to conventional RBFS in permanent molars affected by MIH in terms of retention, marginal integrity, caries prevention effect, and sensitivity.

Key facts

Study ID

NCT07504614

Run by

Jordan University of Science and Technology

People needed

76

Starts

2025-08-01

Expected to finish

2027-08-30

Last updated by the study team

2026-04-01

Who can join

Age: 6 and older, up to 12. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 6-12-year-old patients with at least one fully erupted first permanent molar (FPM) diagnosed with MIH defects (White, creamy, or yellow to brownish opacities greater than one millimetre) without posteruptive enamel breakdown or caries (ICDAS code 0 or 1).
• Non -contributory medical history
• Children must exhibit sufficient cooperation for treatment.
• FPMs status of eruption must allow for proper isolation. Exclusion Criteria:-
• Medically compromised patient.- Partially erupted MIH first permanent molars that could not be sufficiently isolated.
• Carious molars.
• Restored MIH molars.
• Sealed MIH molars.
• MIH molars with extensive enamel breakdown that requires restoration.
• MIH molars planned for extraction (compensatory or balancing extraction) as part of elective extraction plan of MIH molars with poor long-term prognosis.
• Molars affected with other enamel defects ((e.g., amelogenesis imperfecta or fluorosis)
• Non-MIH affected molars.
• Parents did not consent for treatment.
• Child not sufficiently cooperative for treatment.

Where it is running

• Jordan University of Science and Technology — Irbid, Jordan

Full record on ClinicalTrials.gov

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