An Exploratory Efficacy and Safety Study of DFL24498 Topical Ophthalmic Solution Compared With Vehicle in Participants With Dry Eye Disease
Recruiting now · Phase 2
Conditions studied: Dry Eye Disease (DED)
In brief
This is a Phase 2, randomized, multicenter, double masked, vehicle controlled, parallel group study to evaluate the efficacy and safety of DFL24498 topical ophthalmic solution versus vehicle in participants with dry eye disease. Approximately 417 participants aged 18 years or older who meet all eligibility criteria will be enrolled at study sites in the US. The study duration will be up to 16 weeks and will consist of three periods.
Key facts
- Study ID
- NCT07503886
- Run by
- Dompé Farmaceutici S.p.A
- People needed
- 417
- Starts
- 2026-05-12
- Expected to finish
- 2027-02-07
- Last updated by the study team
- 2026-06-26
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Arizona Eye Center — Chandler, Arizona, United States (enrolling)
- Canyon City Eyecare — Azusa, California, United States (enrolling)
- Global Research Management, Inc. — Glendale, California, United States (enrolling)
- United Medical Research Institute — Inglewood, California, United States (enrolling)
- Eye Research Foundation — Newport Beach, California, United States (enrolling)
- NVision Clinical Research, LLC — Torrance, California, United States (enrolling)
- Clayton Eye Clinical Research — Morrow, Georgia, United States (enrolling)
- Price Vision Group / Cornea Research Foundation of America — Indianapolis, Indiana, United States (enrolling)
- Oculus Research, Inc. — Garner, North Carolina, United States (enrolling)
- Scott & Christie and Associates, PC — Cranberry Township, Pennsylvania, United States (enrolling)
- Total Eye Care, PA - Memphis — Memphis, Tennessee, United States (enrolling)
- Lake Travis Eye and Laser Center — Lakeway, Texas, United States (enrolling)
- Piedmont Eye Center — Lynchburg, Virginia, United States (enrolling)
- Comprehensive Eye Care, Ltd. — Washington, Missouri, United States
- Asheville Eye Associates - Regional Medical Park — Asheville, North Carolina, United States
- LoBue Laser and Eye Medical Center — Murrieta, California, United States
- Alpine Research Organization, Inc. — Clinton, Utah, United States
- Core, Inc. — Shelby, North Carolina, United States
- Shettle Eye Research, Inc. — Largo, Florida, United States
- University of South Florida - Marshall Student Center — Tampa, Florida, United States
- Cincinnati Eye Institute — Mason, Ohio, United States
- Houston Eye Associates — Houston, Texas, United States
- Minnesota Eye Consultants — Minnetonka, Minnesota, United States
- Tekwani Vision Center — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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