AMAZE 12: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Maintain Their Weight Loss

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Obesity

In brief

The purpose of this clinical study is to find out if NNC0487-0111 is safe and effective for treating people who have excess body weight. There are 2 study treatments in this study taken as injections under the skin once a week. Participants will either get NNC0487-0111 (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participants get is decided by chance.

Key facts

Study ID

NCT07503210

Run by

Novo Nordisk A/S

People needed

600

Starts

2026-04-21

Expected to finish

2028-07-04

Last updated by the study team

2026-07-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female (sex at birth).
• Age 18 years or above at the time of signing the informed consent.

You may not qualify if…

• Glycated haemoglobin (HbA1c) greater than or equal to ≥ 6.5% [48 millimoles per mole (mmol/mol)] as measured by the central laboratory at screening.
• History of type 1 or type 2 diabetes mellitus as declared by the participant or reported in the medical records.
• Treatment with glucagon-like-peptide-1 (GLP-1) receptor agonists (RA), dual GLP 1/gastric inhibitory peptide (GIP) RAs (or any other GLP-1 based treatment), or amylin analogues before screening.

Where it is running

• Pinnacle Research Group LLC — Anniston, Alabama, United States (enrolling)
• DCC 1 - Lom EOOD — Lom, Bulgaria (enrolling)
• Endeavor Health — Skokie, Illinois, United States (enrolling)
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States (enrolling)
• Florida Inst For Clin Res LLC — Orlando, Florida, United States (enrolling)
• PMG Research of Wilmington LLC — Wilmington, North Carolina, United States (enrolling)
• UPA Ctr Weight and Eating Dis — Philadelphia, Pennsylvania, United States (enrolling)
• Clinical Res Collaborative — Cumberland, Rhode Island, United States (enrolling)
• Midwest Inst For Clin Res — Indianapolis, Indiana, United States (enrolling)
• UT Southwestern Med Cntr — Dallas, Texas, United States (enrolling)
• Medication Mgmnt, LLC_Grnsboro — Greensboro, North Carolina, United States (enrolling)
• Rainier Clin Res Ctr Inc — Renton, Washington, United States (enrolling)
• Conexa — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina (enrolling)
• CICEMO- Consultorio (Av Directorio) — Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina (enrolling)
• Instituto de Investigaciones Clinicas Mar Del Plata — Mar del Plata, Buenos Aires, Argentina (enrolling)
• CIPREC Pueyrredon — Buenos Aires, Argentina (enrolling)
• Sydney Clinical Trials — Campbelltown, New South Wales, Australia (enrolling)
• Sydney Cardiometabolic Centre — Liverpool, New South Wales, Australia (enrolling)
• Hunter Diabetes Centre — Merewether, New South Wales, Australia (enrolling)
• Nightingale Research — Adelaide, South Australia, Australia (enrolling)
• Anima Research Center — Diepenbeek, Belgium (enrolling)
• AZ Groeninge - Kortrijk - Centrum Endo - Diabetologie — Kortrijk, Belgium (enrolling)
• Centre hospitalier universitaire de Liège (CHU de Liège) — Liège, Belgium (enrolling)
• Selma Medical Associates — Winchester, Virginia, United States (enrolling)
• MHAT Med Line Clinic — Plovdiv, Bulgaria (enrolling)

Full record on ClinicalTrials.gov

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