A Study on the Efficacy of 2% Cholesterol Cream in Atopic Dermatitis

Enrolling by invitation · Not applicable · Has a placebo group

Conditions studied: Atopic Dermatitis (AD), Cholesterol, Skin Barrier to Water Loss, Skin Allergy, Eczema Atopic Dermatitis, Trans Epidermal Water Loss

In brief

Atopic dermatitis is a common chronic inflammatory skin condition characterized by impaired skin barrier function, leading to increased transepidermal water loss (TEWL), dry skin, and itching. Restoration of the skin barrier is an important component of treatment. Cholesterol is a key lipid in the stratum corneum that plays a role in maintaining skin barrier integrity. This study aims to evaluate the efficacy and safety of 2% cholesterol cream in improving skin barrier function and clinical symptoms in patients with mild to moderate atopic dermatitis aged 7-17 years. Participants will be randomly assigned to receive either 2% cholesterol cream or a placebo (cream base), applied twice daily for 12 weeks. Outcomes will include measurements of transepidermal water loss (TEWL), skin hydration, skin pH, Investigator's Global Assessment (IGA), Eczema Area and Severity Index (EASI), and pruritus numeric rating scale (NRS). The results of this study may support the use of cholesterol-containing topical formulations as a safe and effective treatment option for atopic dermatitis.

Key facts

Study ID

NCT07503197

Run by

Institute of Dermatology, Thailand

People needed

30

Starts

2026-04-01

Expected to finish

2027-02-14

Last updated by the study team

2026-05-14

Who can join

Age: 7 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Thai nationality
• Aged between 7-17 years
• Able to read and write Thai fluently
• Clinically diagnosed with mild to moderate atopic dermatitis, with lesions located on both antecubital fossae, according to the Hanifin and Rajka criteria
• Investigator's Global Assessment (IGA) score of 1-3
• Eczema Area and Severity Index (EASI) score between 0.2-21

You may not qualify if…

• Presence of other dermatologic conditions other than atopic dermatitis
• Use of systemic immunosuppressive therapy (e.g., prednisolone, dupilumab, JAK inhibitors)
• History of chronic infections such as hepatitis B, hepatitis C, herpes zoster, or tuberculosis
• History of any malignancy
• Pregnant or breastfeeding women, or those planning pregnancy during the study period

Where it is running

• Institute of dermatology(inderm) — Bangkok, Thailand

Full record on ClinicalTrials.gov

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