Optimizing Endoscopic and Interventional Treatment for Portal Hypertensive Bleeding

Starting soon

Conditions studied: Portal Hypertension, Gastroesophageal Varices Hemorrhage, Gastric Varices, Esophageal Varices

In brief

This study aims to evaluate the impact of high-risk factors-such as elevated portal venous pressure, concurrent large extra-luminal vessels, portal vein thrombosis, and prominent portosystemic shunts-on the efficacy of endoscopic therapy. By comparing with interventional treatment, the goal is to optimize the clinical management protocol for esophageal and gastric varices, enhance the therapeutic outcomes of portal hypertension-related esophageal and gastric varices, and improve patient prognosis.

Key facts

Study ID

NCT07502729

Run by

Shanghai Zhongshan Hospital

People needed

1066

Starts

2026-03-17

Expected to finish

2027-12-31

Last updated by the study team

2026-03-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Admitted due to gastrointestinal bleeding and clinically diagnosed with portal hypertension
• Underwent imaging examinations and gastroscopy within one week after admission
• Gastroscopy revealed the presence of esophageal and/or gastric varices
• Age over 18 years

You may not qualify if…

• Previous history of liver transplantation
• Imaging or gastroscopy findings indicated ulcers or other causes of gastrointestinal bleeding
• Concurrent severe life-threatening diseases involving the circulatory, hematological, or respiratory systems
• Difficulty in follow-up, or lack of essential medical history information, imaging data, or other necessary records

Full record on ClinicalTrials.gov

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